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* '''Day 8:''' stop administration of trazodone.
| start =
* A wash-out period is not necessary, but care is needed.
* '''Day 8:''' start administration of duloxetine in a normal dosage of 60 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Duloxetine is a strong inhibitor of CYP2D6, which metabolizes trazodone.}}
