| to = hypericum
| stop =
* '''Before day 0:''' gradually reduce dosage of sertraline to a maximum of 50 mg/day, when this dosage is > 50 mg/day. * '''Day 1:''' reduce dosage of sertraline to 25 mg/day.* '''Day 8:''' stop administration of sertraline.{{stopSertraline}}
| start =
* '''Day 89-1423:''' a wash-out period of at least one week is necessary.* '''Day 1524:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).| caveat = {{caveSS}} {{Lit-SSRI-Hypericum}} {{Lit-SSRI-Hypericum2}}| info = {{HypericumInfo}}* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Hypericum slows the metabolism of sertraline via CYP3A4. }}