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Created page with '{{ Drugswitch | from = amitriptyline | to = hypericum | stop = * '''Before day 0:''' gradually reduce dosage of amitriptyline to a maximum of 50 mg/day, when this dosage is >...'
{{ Drugswitch
| from = amitriptyline
| to = hypericum
| stop =
* '''Before day 0:''' gradually reduce dosage of amitriptyline to a maximum of 50 mg/day, when this dosage is > 50 mg/day.
* '''Day 1:''' reduce dosage of amitriptyline to 25 mg/day.
* '''Day 8:''' stop administration of amitriptyline.
| start =
* '''Day 8-14:''' a wash-out period of one week is necessary.
* '''Day 15:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Hypericum slows the metabolism of amitriptyline via CYP3A4.}}
| from = amitriptyline
| to = hypericum
| stop =
* '''Before day 0:''' gradually reduce dosage of amitriptyline to a maximum of 50 mg/day, when this dosage is > 50 mg/day.
* '''Day 1:''' reduce dosage of amitriptyline to 25 mg/day.
* '''Day 8:''' stop administration of amitriptyline.
| start =
* '''Day 8-14:''' a wash-out period of one week is necessary.
* '''Day 15:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Hypericum slows the metabolism of amitriptyline via CYP3A4.}}
