838
edits
Changes
Created page with '{{ Drugswitch | from = clomipramine | to = hypericum | stop = * '''Before day 0:''' gradually reduce dosage of clomipramine to a maximum of 75 mg/day, when this dosage is > 7...'
{{ Drugswitch
| from = clomipramine
| to = hypericum
| stop =
* '''Before day 0:''' gradually reduce dosage of clomipramine to a maximum of 75 mg/day, when this dosage is > 75 mg/day.
* '''Day 1:''' reduce dosage of clomipramine to 50 mg/day.
* '''Day 8:''' reduce dosage of clomipraminde to 25 mg/day.
* '''Day 15:''' stop administration of clomipramine.
| start =
* '''Day 8-14:''' a wash-out period of one week is necessary.
* '''Day 15:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Hypericum slows the metabolism of clomipramine via CYP3A4. }}
| from = clomipramine
| to = hypericum
| stop =
* '''Before day 0:''' gradually reduce dosage of clomipramine to a maximum of 75 mg/day, when this dosage is > 75 mg/day.
* '''Day 1:''' reduce dosage of clomipramine to 50 mg/day.
* '''Day 8:''' reduce dosage of clomipraminde to 25 mg/day.
* '''Day 15:''' stop administration of clomipramine.
| start =
* '''Day 8-14:''' a wash-out period of one week is necessary.
* '''Day 15:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Hypericum slows the metabolism of clomipramine via CYP3A4. }}
