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* '''Day 15:''' stop administration of doxepin.
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* '''Day 815-1422:''' a wash-out period of one week is necessary.* '''Day 1523:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Hypericum slows the metabolism of doxepin via CYP3A4. }}
