Changes

* Gradually '''Before day 0:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/ day. * When a '''Day 1:''' reduce the dosage of 300 moclobemide to 150 mg/day is reached, .* '''Day 8:''' stop administrationof moclobemide.

* No wash-out period is needed. * Start '''Day 9:''' start administration of imipramine the next day in a normal dosage of 25-75 mg/day.}}