Changes

Administration * '''Before day 0:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day. * '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.* '''Day 8:''' stop administration of moclobemide can be stopped abruptly.

* '''Day 18-29:''' a wash-out period of two days is necessary. * '''Day 310:''' start maprotiline after this period in a normal dosage of 25-75 mg/day.