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* '''Before day 0:''' gradually reduce dosage of fluvoxamine to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
* '''Day 1:''' reduce fluvoxamine to a dosage of 25 mg/day.
* '''Day 8:''' stop administration of fluvoxamine.
| start =
* '''Day 18:''' simultaneously start administration of mirtazapine in a low dosage of 15 mg/day for one week.* '''Day 815:''' stop administration of fluvoxamine and continue administration of just mirtazapine. If necessary increase dosage of mirtazapine to normal (30 mg/day).| info = * Caution with this switch is necessary, because fluvoxamine slows the metabolism of mirtazapine via CYP1A2, CYP2C9, CYP2D6 and CYP3A4. The inhibiting effect can continue up to two weeks after stopping fluvoxamine.}}
