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* '''Day 0:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
* '''Day 1:''' reduce a dosage of 30 mg/day to 15 mg/day.
* '''Day 8:''' stop administration of mirtazapine.
| start =
No wash-out period is needed.
* '''Day 1:''' simultaneously start administration of amitriptyline in a dosage of 50 mg/day.
* '''Day 8:''' stop administration of mirtazapine and continue administration of amitriptyline. If necessary, increase dosage of amitriptyline.
* Start low, go slow.}}
