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Trazodone-paroxetine

31 bytes added, 12:37, 10 July 2009
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* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
* '''Day 1:''' reduce dosage of trazodone to 75 -100 mg/day.
* '''Day 8:''' stop administration of trazodone.
| start =
* '''Day 8:''' start administration of paroxetine in a normal dosage of 20 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes trazodone.* The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given. }}
Walter
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