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| to = trazodone
| stop =
* Administration '''Day 1-14:'''Gradually decrease the dosage of hypericum. * '''Day 15:''' stop administration of hypericum can be stopped abruptly.| start = * '''Day 115-730:''' a wash-out period of one week at least two weeks is necessary.* '''Day 831:''' start administration of trazodone in a dosage of 100-150 mg/day.* '''Day 15:''' increase dosage of trazodone to 300 mg/day.* If necessary, increase dosage of trazodone further.
| info =
* Occurrence of the serotonin syndrome is theoretically possiblewithout wash-out period.* Hypericum induces enzymes of the CYP P-450 type and P-gp.* Hypericum probably has MAO-inhibiting properties. }}
