Changes

* '''Day 1-714:''' a wash-out period Gradually decrease the dosage of one week is necessaryhypericum.* '''Day 815:''' start stop administration of venlafaxine in hypericum.| start = * '''Day 15-30:''' a dosage wash-out period of 37,5 mg/dayat least two weeks is necessary.* '''Day 1531:''' increase dosage of start venlafaxine to 37,5 mg or 75 mg(slow release)/day.* If necessary, increase dosage of venlafaxine further.

* Occurrence of the serotonin syndrome is theoretically possiblewithout wash-out period.* Hypericum slows induces enzymes of the metabolism of venlafaxine via CYP3A4CYP P-450 type and P-gp. This effect may persist up to two weeks after stopping hypericum, so caution is necessary* Hypericum probably has MAO-inhibiting properties.}}