* '''Day 15-30:''' a wash-out period of at least two weeks is necessary.
* '''Day 31:''' start sertraline 25-50 mg/day.
| info caveat =
* Occurrence of the serotonin syndrome is possible without wash-out period.
* Hypericum induces enzymes of the CYP P-450 type and P-gp.| info ={{HypericumInfo}}* Hypericum probably has MAO-inhibiting properties.}}