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* '''Day 0:''' gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
* '''Day 1:''' reduce dosage of paroxetine to a maximum of 10 mg/day.
* '''Day 8:''' reduce stop dosage of paroxetine to 5 mg/day.
| start =
Caution is necessary.
* '''Day 8:''' simultaneously start administration of maprotiline in a low dosage of 25 mg/day. * '''Day 15:''' stop administration of paroxetine and only continue increase administration of maprotiline in to a dosage of 50-100 mg/day.
* "Start low, go slow" is not required, but caution is necessary!
| info =
* Paroxetine slows the metabolism of maprotiline via CYP1A2 and CYP2D6. }}
