Changes

* Gradually '''Before day 0:''' gradually reduce dosage of clomipramine to a maximum of 75 mg/day, when this dosage is > 75 mg/day. * When a '''Day 1:''' reduce dosage of clomipramine to 50 mg/day.* '''Day 8:''' reduce dosage of 75 clomipramine to 25 mg/day is reached, .* '''Day 15:''' stop administrationof clomipramine.

* No wash-out period is needed. * Start '''Day 8:''' start administration of nortriptyline the next day in a normal dosage of 25 mg/day. * '''Day 15:''' increase dosage of nortriptyline to 50 mg/day.* '''Day 22:''' increase dosage of nortriptyline.}}