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Maprotiline-sertraline

86 bytes removed, 13:58, 31 July 2009

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* '''Day 3:''' reduce dosage of maprotiline to 25 mg/day.

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* '''Day 13:''' simultaneously start administration of sertraline in a normal dosage of 50 mg/day.

* '''Day 8:''' stop administration of maprotiline and continue administration of sertraline in a dosage of 50-100 mg/day.

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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Sertraline is a weak inhibitor of CYP2D6, which metabolizes maprotiline. }}

Walter

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Psychiatrienet β

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Maprotiline-sertraline

Psychiatrienet ^β