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* '''Before Day 0:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
* '''Day 1:''' reduce a dosage of 30 mg/day to 15 mg/day.
* '''Day 7:''' stop mirtazapine.
| start =
* '''Day 18:''' simultaneously start sertraline in a normal dosage of 50 mg/day.* '''Day 814:''' stop administration if necessary increase dosage of sertraline.| info = * Sertraline slows dose-dependently the metabolism of mirtazapine and only continue administration of sertralinethrough CYP2D6.
}}
