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* '''Before day 0:''' gradually reduce dosage of doxepin to a maximum of 100 mg/day.
* '''Day 1:''' reduce dosage of doxepin to 50 mg/day.
* '''Day 38:''' reduce dosage of doxepin to 25 mg/day.* '''Day 15:''' stop administration of doxepin.
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* '''Day 115:''' simultaneously start administration of sertraline in a normal dosage of 50 mg/day.* '''Day 822:''' stop administration of doxepin and continue administration of if necessary increase sertraline in a dosage of 50-to 100 mg/day.
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}
* Sertraline is a weak inhibitor of CYP2D6, which metabolizes doxepin. }}
