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Caution is necessary for at least four weeks.
* '''Day 1:''' start administration of maprotiline in a low dosage of 25 mg/day.
* '''Day 1514:''' increase dosage of maprotiline to 50 mg/day.
* '''Day 28:''' gradually increase dosage of maprotiline to 75 mg/day and more.
| info =
* Fluoxetine slows and norfluoxetine slow the metabolism of maprotiline via CYP2D6.
* Start low, go slow for maprotiline.
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