* When a dosage of 150 mg/day is reached, stop administration.
| start =
* '''Day 1-7:''' a No wash-out period of at least one week is necessaryneeded. * '''Day 8:''' start Start paroxetine with the next day in normal dosage of 20 mg/day.
| info =
* By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.
* Bupropion slows the metabolism of paroxetine by CYP2D6.}}