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* '''Day 1:7 and after''' simultaneously : At approximately 50-25% of the original TCA dose start administration of paroxetine in a normal dosage at 50% of 20 mg/daythe target dose.* '''Day 814:''' stop administration Increase paroxetine to 100% of amitriptyline and continue administration of paroxetine.the target dose
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* Occurrence of serotonin syndrome Safe target dose paroxetine = 20 mg* paroxetine is theoretically possiblea strong CYP2D6 inhibitor, so caution is necessarywhich metabolize amitriptyline.}}
