Changes

| base = Lamotriginelamotrigine| add = Lithiumlithium

* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.* This combination of drugs may have possible synergistic effectsbe rational, but more data is needed.<ref name=”freeman”> {{Pubmed|9433333|Freeman et al. However, this combination will also have additive side effectsMood stabilizer Combinations: A Review of Safety and Efficacy. Dose adaptation will be recommended for this combinationAm J Psychiatry 1998;155:12-21}}</ref>.

* Lamotrigine does not cause a significant change in the pharmacokinetics of lithium. Start lithium according to the general dosing advice. <ref> {{Pubmed| 10971302 |Chen C at al, The effects of lamotrigine on the pharmacokinetics of lithium. Br J Clin Pharmacol 2000;50(3):193-5}}</ref>| cave =* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects.<ref name="drugscominteract"> {{Drugscominteract|lamotrigine-with-lithium-1477-0-1430-0|lamotrigine|lithium}}</ref>