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Combining-Carbamazepine-Risperidone

807 bytes added, 15:31, 4 March 2010
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{{Drugcombi| base = Carbamazepine| add = Risperidone| info = * Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.* Risperidone is principally metabolized by CYP2D6 to an active metabolite.* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.| start = * Coadministration with carbamazepine may decrease the plasma concentrations of risperidone and its pharmacologically active metabolite, 9-hydroxyrisperidone.* Risperidone should be given at higher dosage to control psychotic symptoms. <ref name="drugscom">{{DRUGSCOM|olanzapine}}</ref>| cave = }}
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