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Created page with '{{Drugcombi | base = Lithium | add = Carbamazepine | info = * Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects. * C...'
{{Drugcombi
| base = Lithium
| add = Carbamazepine
| info =
* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* The combination may rarely cause neurotoxicity ''without increased plasma levels''.
| cave =
}}
| base = Lithium
| add = Carbamazepine
| info =
* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* The combination may rarely cause neurotoxicity ''without increased plasma levels''.
| cave =
}}
