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* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
| start =
* Start olanzapine according to the general dosing advice. Monitoring of the liver function every 3 to 4 months during the first year of treatment with either olanzapine or valproic acid is recommended.<ref name="drugscom">{{DRUGSCOMDrugscominteract|olanzapine-with-valproic-acid-1744-0-2286-0|olanzapine|valproic acid}}</ref>
| cave =
* Concurrent use of olanzapine and valproic acid may potentiate the risk of hepatotoxicity. <ref name="drugscom">{{DRUGSCOM|olanzapine}}</ref>
}}
