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* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
* Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.<ref> {{Pubmed|18579216|Vieta E at al, Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). J Affect Disord. 2008 Aug;109(3):251-63. Epub 2008 Jun 24}}</ref>
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* Start quetiapine according to the general dosing advice.
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* During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. <ref name="drugscom">
{{Drugscominteract|quetiapine-with-valproic-acid-1979-1274-2286-0|quetiapine|valproic acid}}</ref>
}}
