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Created page with '{{Drugcombi | base = olanzapine | add = lithium | info = * Olanzapine is principally metabolized by CYP1A2 and CYP2D6. * Lithium is eliminated by the kidney for about 95%. Chang...'
{{Drugcombi
| base = olanzapine
| add = lithium
| info =
* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start lithium according to the general dosing advice.
| cave =
* The concomitant administration of lithium with neuroleptic agents may increase the risk of extrapyramidal reactions and neurotoxicity. <ref name="drugscom">
{{Drugscominteract|olanzapine-with-lithium|olanzapine|lithium}}</ref>
}}
| base = olanzapine
| add = lithium
| info =
* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start lithium according to the general dosing advice.
| cave =
* The concomitant administration of lithium with neuroleptic agents may increase the risk of extrapyramidal reactions and neurotoxicity. <ref name="drugscom">
{{Drugscominteract|olanzapine-with-lithium|olanzapine|lithium}}</ref>
}}
