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Created page with '{{Drugcombi | base = olanzapine | add = topiramate | info = * Olanzapine is principally metabolized by CYP1A2 and CYP2D6. * Topiramate induces CYP3A4 and is an inhibitor of CYP2...'
{{Drugcombi
| base = olanzapine
| add = topiramate
| info =
* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
* Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start topiramate according general dosing advice.
| cave =
* Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. <ref name="drugscom">
{{Drugscominteract|olanzapine-with-topiramate|olanzapine|topiramate}}</ref>
}}
| base = olanzapine
| add = topiramate
| info =
* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
* Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start topiramate according general dosing advice.
| cave =
* Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. <ref name="drugscom">
{{Drugscominteract|olanzapine-with-topiramate|olanzapine|topiramate}}</ref>
}}
