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Created page with '{{Drugcombi | base = gabapentin | add = olanzapine | info = * Gabapentine is eliminated unchanged by the kidney for 100%. * Olanzapine is principally metabolized by CYP1A2 and C...'
{{Drugcombi
| base = gabapentin
| add = olanzapine
| info =
* Gabapentine is eliminated unchanged by the kidney for 100%.
* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
* This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. <ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>
| start =
* Start olanzapine according to the general dosing advice.
| cave =
* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom">
{{Drugscominteract|olanzapine-with-gabapentin-1147-0-1744-1113|olanzapine|gabapentin}}</ref>
}}
| base = gabapentin
| add = olanzapine
| info =
* Gabapentine is eliminated unchanged by the kidney for 100%.
* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
* This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. <ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>
| start =
* Start olanzapine according to the general dosing advice.
| cave =
* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom">
{{Drugscominteract|olanzapine-with-gabapentin-1147-0-1744-1113|olanzapine|gabapentin}}</ref>
}}
