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* Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
* Gabapentine is eliminated unchanged by the kidney for 100%.
* This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. <ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>
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* Start gabapentine according to the general dosing advice.
