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Created page with '{{Drugswitch | from = sertraline | to = imipramine | stop = * '''Day 0:''' gradually reduce dosage of sertraline to a maximum of 50 mg/day when this dosage is > 50 mg/day. *...'
{{Drugswitch
| from = sertraline
| to = imipramine
| stop =
* '''Day 0:''' gradually reduce dosage of sertraline to a maximum of 50 mg/day when this dosage is > 50 mg/day.
* '''Day 1:''' reduce dosage of sertraline to a maximum of 25 mg/day.
| start =
Caution is necessary.
* '''Day 1:''' simultaneously start administration of imipramine in a low dosage of 25 mg/day.
* '''Day 8:''' stop administration of sertraline and only continue administration of imipramine in a dosage of 50 mg/day.
* Start low, go slow!
| info =
* Sertraline dose-dependently slows the metabolism of imipramine via CYP2C9 and CYP2D6. }}
| from = sertraline
| to = imipramine
| stop =
* '''Day 0:''' gradually reduce dosage of sertraline to a maximum of 50 mg/day when this dosage is > 50 mg/day.
* '''Day 1:''' reduce dosage of sertraline to a maximum of 25 mg/day.
| start =
Caution is necessary.
* '''Day 1:''' simultaneously start administration of imipramine in a low dosage of 25 mg/day.
* '''Day 8:''' stop administration of sertraline and only continue administration of imipramine in a dosage of 50 mg/day.
* Start low, go slow!
| info =
* Sertraline dose-dependently slows the metabolism of imipramine via CYP2C9 and CYP2D6. }}
