[[File{{Drugswitch | from = vortioxetine | to = bupropion| stop = * '''Day 1:Empty''' reduce dosage of vortioxetine to 5 mg/day.jpg]]* '''Day 7:''' stop administration of vortioxetine.| start = * '''Day 7:''' stop administration of vortioxetine and simultaneously start administration of bupropion in a dosage of 150 mg/day.* '''Day 14:''' stop administration of vortioxetine and continue administration of bupropion.| info = * Bupropion is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. Combination of vortioxetine and bupropion can lead to adverse effects of vortioxetine.* Vortioxetine has a biological half-life of 66 hours. Reduction to the lowest effective dose of vortioxetine probably prevents adverse effects of vortioxetine due to lower blood levels of vortioxetine. }}
