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| to = vortioxetine
| stop =
* '''Before day 1:''' Gradually reduce dosage of bupropion to a maximum of 150 mg/ day. * '''Day 1:''' When a dosage of 150 mg/day is reached, stop administration.
| start =
* A wash-out period is not necessary.* Start '''Day 1:''' start administration of vortioxetine the next day in a normal dosage of 10 mg/day.* '''Day 8:''' if necessary, increase dosage of sertraline.
| info =
* Bupropion and its metabolites have long elimination times (t1/2: 20-37 hours), so plasma concentrations will reduce gradually.
}}
