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| to = vortioxetine
| stop =
* '''Before day 8Day 1:''' Gradually reduce dosage of bupropion to a maximum of 150 mg/ day. * '''Day 8:''' When a dosage of 150 mg/day is reached, stop administrationof bupropion.
| start =
{{washout8-14}}
* '''Day 1415:''' start administration of vortioxetine in a normal dosage of 10 mg/day.
| info =
* Bupropion and its metabolites have long elimination times (t1/2: 20-37 hours), so plasma concentrations will reduce gradually. Bupropion is an inhibitor of CYP2D6.
}}
