838
edits
Changes
Created page with '{{Drugswitch | from = nortriptyline | to = fluoxetine | stop = * '''Before day 0:''' gradually reduce dosage of nortriptyline to a maximum of 50 mg/day. * '''Day 1:''' reduce...'
{{Drugswitch
| from = nortriptyline
| to = fluoxetine
| stop =
* '''Before day 0:''' gradually reduce dosage of nortriptyline to a maximum of 50 mg/day.
* '''Day 1:''' reduce dosage of nortriptyline to 25 mg/day.
* '''Day 3:''' reduce dosage of nortriptyline to 10 mg/day.
| start =
* '''Day 1:''' simultaneously start administration of fluoxetine in a normal dosage of 20 mg/day.
* '''Day 8:''' stop administration of nortriptyline and continue administration of fluoxetine.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes nortriptyline. }}
| from = nortriptyline
| to = fluoxetine
| stop =
* '''Before day 0:''' gradually reduce dosage of nortriptyline to a maximum of 50 mg/day.
* '''Day 1:''' reduce dosage of nortriptyline to 25 mg/day.
* '''Day 3:''' reduce dosage of nortriptyline to 10 mg/day.
| start =
* '''Day 1:''' simultaneously start administration of fluoxetine in a normal dosage of 20 mg/day.
* '''Day 8:''' stop administration of nortriptyline and continue administration of fluoxetine.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes nortriptyline. }}
