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Doxepine-sertraline

486 bytes removed, 13:01, 20 February 2025
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| to = sertraline
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* '''Before day 0:''' gradually reduce dosage of doxepin to a maximum of 100 mg/day.* '''Day 1:''' reduce dosage of doxepin to 50 mg/day.* '''Day 3:''' reduce dosage of doxepin to 25 mg/day.{{TCAdecrease25p3d}}| start = {{StartAntidepressant}}* '''Day 1:''' simultaneously start administration of sertraline in a normal dosage of 50 mg/day.| info =* '''Day 8:''' stop administration of doxepin and continue administration of Safe target dose sertraline in a dosage of 50-= 100 mg/day.| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Sertraline is a weak inhibitor of CYP2D6, which metabolizes doxepin. }}

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