99
edits
Changes
no edit summary
| to = imipramine
| stop =
{{stopFluoxetine1stopfluox}}
| start =
Caution is necessary for at least four weeks.
* '''Day 25:''' start administration of imipramine in a low dosage of 25 mg/day.
* '''Day 15:''' increase dosage of imipramine to 50 mg/day.
* '''Day 2920 and after:''' gradually increase dosage of imipramine to 75 mg/day and moreif necessary.
| info =
* {{TCAplasmalevelmonitoring}}
* Tapering fluoxetine to 20mg before stopping is not necessary, because of strong serotonergic activity of target drug.
{{longt1/2fluvox}}
* Fluoxetine and norfluoxetine slow the metabolism of imipramine via CYP2D6.
* Start low, go slow for imipramine.
}}
