Changes

| to = fluoxetine

{{stopAmitriptyline1TCAdecrease25p3d}}

* '''Day 8:6 and after''' : At approximately 50-25% of the original TCA dosering start administration of fluoxetine in a normal dosage at 100% of 20 mg/daythe target dose.* '''Day 15After 3 weeks:''' if If necessary, gradually increase dosage of fluoxetine. 

{{theorSS}}* Safe target dose fluoxetine = 20 mg* Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) and CYP3A4 which metabolizes nortriptyline, (moderatea metabolite of amitriptyline), which metabolize amitriptyline.