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Imipramine-bupropion

231 bytes removed, 11:48, 4 November 2015
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* '''Before day 1:''' gradually reduce dosage of imipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.* '''Day 1-3:''' reduce dosage of imipramine to 50 mg/day.* '''Day 4-7:''' reduce dosage of imipramine to 25 mg/day.{{stopImipramine}}
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* '''Day 4:''' simultaneously start administration of bupropion in a dosage of 150 mg/day and continue administration of imipramine according to the scheme above.
* Bupropion is a strong inhibitor of CYP2D6, which metabolizes imipramine.
* {{RiskSeizureBupropionTCA}}
{{review}}
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