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Clomipramine-fluoxetine

256 bytes removed, 11:59, 4 November 2015
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* '''Before day 1:''' gradually reduce dosage of clomipramine to a maximum of 50 mg/day.* '''Day 1:''' reduce dosage of clomipramine to 25 mg/day.* '''Day 8:''' stop dosage of clomipramine.{{stopClomipramine}}
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* '''Day 89:''' start administration of fluoxetine in a normal dosage of 20 mg/day.
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}
* Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) and CYP3A4 (moderate), which metabolize clomipramine.
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