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* '''Day 4-7:''' reduce dosage of imipramine to 25 mg/day.
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* '''Day 1:''' ** simultaneously start administration of bupropion in a dosage of 150 mg/day and ** continue administration of imipramine according to the scheme above.* '''Day 8:''' ** stop administration of imipramine and ** continue administration of bupropion only in a dosage of 300 mg/day.
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* Bupropion is a strong inhibitor of CYP2D6, which metabolizes imipramine. }}
