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A wash-out period of one week is necessary.
* '''Day 1-7:''' wash-out period
* '''Day 8-14:''' start tranylcypromine at half the usual dosage for one week, 20 mg/day. * '''Day 15:''' start normal increase dosage of tranylcypromine, 20 mg/daytranylcypromineif necessary.
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* By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur. }}
