{{Inc25p3d2}}* '''Day 1:''' start administration of maprotiline in a low dosage of 25 mg/day. * '''Day 8:''' increase administration of maprotiline to a dosage of 50 mg/day.
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* Bupropion slows the metabolism of maprotiline via CYP2D6.
* Caution is necessary at the start of administration of maprotiline.
