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Fluvoxamine-agomelatine

330 bytes added, 11:41, 4 August 2023
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| * '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.<ref name= "agoswitch"> {{StartAgomelatinePubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>* '''Day 11:''' If necessary, increase dosage of agomelatine to 50 mg/day.
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* Fluvoxamine inhibits the metabolism of agomelatine via CYP1A2 (90%) and via CYP2C9/2C19 (10%).<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
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