Combining-Gabapentin-Quetiapine
From Psychiatrienet
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Adding quetiapine to gabapentin.
General information- Gabapentin is eliminated unchanged by the kidney for 100%.
- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
- This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. [6]
Start quetiapine- Start quetiapine according to the general dosing advice.
Cave- Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. [5]
- ↑ Farmacotherapeutisch Kompas - gabapentine (dutch)
- ↑ 2.0 2.1 2.2 KNMP; Informatorium Medicamentorum 2023; Monografie "quetiapine" (Dutch)
- ↑ NVZA; Toxicology.org; Monografie 73 (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 5.0 5.1 Drugs.com quetiapine-fumarate Cite error: Invalid
<ref>tag; name "drugscom" defined multiple times with different content - ↑ Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
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