Changes

* Gradually '''Before day 0:''' gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day. * When a '''Day 1:''' reduce dosage of 50 sertraline to 25 mg/day is reached, .* '''Day 8:'''stop administrationof sertraline.

* No wash-out period is needed. * Start '''Day 9:''' start duloxetine the next day in normal dosage of 60 mg/day.}}