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* '''Before day 0:''' gradually reduce dosage of maprotiline to a maximum of 75 mg/day.
* '''Day 1:''' reduce dosage of maprotiline to 50 mg/day.
* '''Day 37:''' reduce dosage of maprotiline to 25 mg/day.* '''Day 14:''' stop dosage of maprotiline.
| start =
* '''Day 37:''' simultaneously start administration of duloxetine in a normal dosage of 60 mg/day.* '''Day 814:''' stop administration of maprotiline and continue administration of duloxetine.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Duloxetine is a inhibitor of CYP2D6, which metabolizes maprotiline.}}
