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* '''Day 1-3:''' reduce dosage of amitriptyline to 50 mg/day.
* '''Day 4-7:''' reduce dosage of amitriptyline to 25 mg/day.
* '''Day 12:''' stop administration of amitriptyline.
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* '''Day 114:''' simultaneously start administration of bupropion in a dosage of 150 mg/day and continue administration of amitriptyline according to the scheme above.* '''Day 8:''' stop administration of amitriptyline and continue administration of bupropion.
| info =
* Bupropion is a strong inhibitor of CYP2D6, which metabolizes amitriptyline.
}}
