Changes

| stop = * '''Before day 1:''' gradually reduce dosage of fluvoxamine to a maximum of 50 mg/ day when this dosage is > 50 mg/day. * '''Day 1:''' reduce dosage of fluvoxamine to a maximum of 25 mg/day. {{StopSSRI,SNRI}}

Caution is necessary* '''Day 1:''' simultaneously start administration of doxepin doxepine in a low dosage of 25 mg25mg/day. * '''Day 8:''' stop administration increase dosage of fluvoxamine and continue administration of doxepin only. If necessary, increase doxepine to a dosage of doxepin75 mg/day.

* Fluvoxamine fluvoxamine slows the metabolism of doxepin doxepine via CYP2D6, and possibly via CYP1A2 tooCYP2C19 inhibition.* "Start low, go slow" is not required, but caution is necessary.{{SSCYPinh}}* {{TCAplasmalevelmonitoring}}}}