387
edits
Changes
Created page with '{{Drugcombi | base = carbamazepine | add = lamotrigine == '''General information''' == * Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent in...'
{{Drugcombi
| base = carbamazepine
| add = lamotrigine
== '''General information''' ==
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels.
== '''Combination''' ===
* Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice.
== '''Caution ''' ==
Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. <ref name="torrentc"> {{Pubmed|12648898|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by
carbamazepine. J Clin Psychiatry 2005;66:400-1}}</ref>
}}
| base = carbamazepine
| add = lamotrigine
== '''General information''' ==
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels.
== '''Combination''' ===
* Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice.
== '''Caution ''' ==
Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. <ref name="torrentc"> {{Pubmed|12648898|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by
carbamazepine. J Clin Psychiatry 2005;66:400-1}}</ref>
}}
